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An extended DNA recombinase toolkit for mammalian systems
Identifying, screening and optimising a novel recombinase toolkit for mammalian cells.
Located in SynBio Fund / An extended DNA recombinase toolkit project folder
Development of a microfluidic device for high-throughput analysis of genetic circuits in plant protoplasts.
This project aims to develop a high-throughput screen for the analysis of promoter sequences driving expression of a reporter gene in plant protoplasts. We envisage this device to be applicable to a range of plant species and cell types, and by coupling it to libraries of regulatory elements identified by DNase-Seq, it will rapidly increase the rate of identifying promoters for biotechnological applications.
Located in SynBio Fund / Microfluidic device for high-throughput analysis of genetic circuits in plant protoplasts. Project folder.
Engineering of self­ cloning brewer’s yeast for novel terpene profiles in beer.
Engineering of self­ cloning brewer’s yeast for novel terpene profiles in beer.
Located in SynBio Fund / Self­ cloning brewer’s yeast project folder
Faster engineering for cyanobacteria
Developing a series of plasmids and a method to rapidly increase production of cyanobacterial mutants with multiple alterations.
Located in SynBio Fund / Faster engineering for cyanobacteria project folder
Flexible, low cost, live­ cell imaging platform
Continued development of a flexible, low cost, live-imaging platform for long term monitoring of cell behaviour in vitro
Located in SynBio Fund / Flexible, low cost, live­ cell imaging platform project folder
High Performance Mechanisms for Low Cost Science
Developing fluorescence and phase contrast functions in a low-cost, 3D-printed microscope and demonstrating its use in an incubator.
Located in SynBio Fund / High Performance Mechanisms for Low Cost Science project folder
Interactive web­-based software for genetic circuit design
This project aims to develop a rigorous design-modeling web-based tool for synthetic biology using a novel design methodology that has been recently developed in the Control Group (Engineering Department).
Located in SynBio Fund / Interactive web­-based software for genetic circuit design project folder
Novel bioluminescent reporters
Finding, testing and generating optimised bioluminescent reporter vectors for use in various organisms.
Located in SynBio Fund / Novel bioluminescent reporters project folder
Reliable IP-free system for inter-chassis transfer of the high molecular weight DNA
This project aims to develop an IP-free system for transfer of the high molecular weight DNA from E. coli to M. polymorpha. This includes development of the plant-specific iBACs for the reliable transfer and integration of the high molecular weight DNA into the M. polymorpha genome. Alternative methods for interchassis DNA transfer, such as integrative and conjugative elements (ICEs) will be also explored.
Located in SynBio Fund / Reliable IP-free system for inter-chassis transfer of the high molecular weight DNA project folder
SynBio Hub
The SynBio Hub platform will allow the scientific community to monitor, review and discover the latest developments in synthetic biology Intellectual Property (IP). The open source platform will initially track all IP being published via the US patent office (USPTO) for relevance to synthetic biology.
Located in SynBio Fund / SynBio Hub project folder