Talk with Prof. Jason Chin [MRC LBM]- Reprogramming the Genetic Code

The information for synthesizing the molecules that allow organisms to survive and replicate is encoded in genomic DNA . In the cell, DNA is copied to messenger RNA , and triplet codons (64) in the messenger RNA are decoded – in the process of translation – to synthesize polymers of the natural 20 amino acids. This process (DNA RNA protein) describes the central dogma of molecular biology and is conserved in terrestrial life. The Chin group is interested in re-writing the central dogma to create organisms that synthesize proteins containing unnatural amino acids and polymers composed of monomer building blocks beyond the 20 natural amino acids. Chin will discuss the invention and synthetic evolution of new ‘orthogonal’ translational components (including ribosomes and aminoacyl-tRNA synthetases) to address the major challenges in re-writing the central dogma of biology. Chin will also cover the application of the approaches developed for incorporating unnatural amino acids into proteins and investigating and synthetically controlling diverse biological processes, with a particular emphasis on understanding the role of post-translational modifications.

This talk is part of the BSS Formal Seminars series.