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[Apply by 2 May 2019] Postdoctoral Fellow in Synthetic Genomics at The Wellcome Sanger Institute, Hinxton

A postdoctoral position is available at the Wellcome Sanger Institute to advance research in human genome synthetic genomics. This position will be led by Tom Ellis and David Adams as part of the Institute’s new Synthetic Genomics Initiative working within the Institute’s Cancer section. The role will coordinate with ongoing research in cancer genomics, and new research in designing and implementing synthetic genomics methods for the human genome. This is an exciting opportunity for the successful candidate to develop and demonstrate state-of-the-art methods for using genome engineering and genomic loci synthesis to synthetically probe the effects of mutation and rearrangement on a major cancer gene. As the goal is focused on showcasing technology development, there will be substantial freedom for the postdoc to guide the research of the project.

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The successful applicant will hold a PhD and will have gained significant experience and expertise in a range of molecular and cell biology techniques. Experience in the following is desired but not essential: genome editing, viral- or transposon-mediated DNA delivery, DNA assembly and manipulation, site-specific integration and microbial synthetic biology. Successful candidates will be expected to drive forward the project, working closely with relevant members of the Institute and the wider scientific community to accomplish scientific objectives.

Job Reference

Essential Skills 

  • A PhD in a relevant area of Biological Sciences, and a passion for problem solving
  • Experience in a range of relevant molecular biology techniques
  • Experience of mammalian cell biology techniques
  • The ability to effectively communicate with collaborators and occasionally present oral communication to large groups
  • Proven independent working style, technical problem solving, data analysis and generation of novel ideas


Ideal Skills

  • Experience in mammalian cell culture and molecular biology
  • Experience in DNA manipulation technologies, especially approaches to deliver and site-specifically integrate large pieces of DNA into genomes
  • Experience in genome editing and engineering
  • Experience in yeast or E. coli synthetic biology


Other information

The Wellcome Sanger Institute is a charitably funded research centre and committed to training the next generation of genome scientists. Focused on understanding the role of genetics in health and disease and a world leader in the genomic revolution, our mission is to use genome sequences to advance understanding of human and pathogen biology in order to improve human health. We aim to provide results that can be translated into diagnostics, treatments or therapies that reduce global health burdens. Our science is large-scale and organised into Programmes, led by our Faculty who conceive and deliver our science, and supported by our Scientific Operations teams responsible for all data production pipelines at the Institute.

Our Campus: Set over 125 acres, the stunning and dynamic Wellcome Genome Campus is the biggest aggregate concentration of people in the world working on the common theme of Genomes and BioData. It brings together a diverse and exceptional scientific community, committed to delivering life-changing science with the reach, scale and imagination to pursue some of humanity’s greatest challenges.

Our Benefits: Our employees have access to a comprehensive range of benefits and facilities including:

  • Defined Contribution Pension Scheme and Life Assurance
  • Group Income Protection
  • Private Health Insurance
  • 25 days annual leave, increasing by one day a year to a maximum of 30
  • Family friendly environment including options for flexible and part-time working, a childcare voucher scheme, Campus Nursery and Summer holiday club
  • Two days paid Employee Volunteering Leave a year
  • Employee Discount Scheme
  • Campus Gym, tennis courts, cricket pitch and sports hall plus a range of dining facilities
  • Active Campus Sports and Social Club
  • Free Campus Bus Service

Genome Research Limited hold an Athena SWAN Bronze Award and will consider all individuals without discrimination and are committed to creating an inclusive environment for all employees, where everyone can thrive.

Please include a covering letter and CV with your application. Closing date for applications: 2nd May 2019

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The Synthetic Biology Strategic Research Initiative provides a hub for anyone interested in Synthetic Biology at the University of Cambridge, as well as commercial partners and external collaborators.