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[Apply by 3 July 2019] Wellcome Sanger Institute seeking Postdoctoral Fellow in Synthetic Genomics (Manchester)

A postdoctoral position is available at the Wellcome Sanger Institute (WSI) to advance research in human genome synthetic genomics. This position will be led by Prof. Patrick Yizhi Cai (University of Manchester, as part of the Institute’s new Synthetic Genomics Initiative working within the Institute’s Cancer section. The role will coordinate with ongoing research in cancer genomics, and new research in designing and implementing synthetic genomics methods for the human genome. This is an exciting opportunity for the successful candidate to develop and demonstrate state-of-the-art methods for using genome engineering and genomic synthesis to synthetically design, synthesize and characterize synthetic mitochondrial genomes. As the goal is focused on showcasing technology development, there will be substantial freedom for the postdoc to guide the research of the project.

More information and application page >>>

The post will initially be based in Manchester Institute of Biotechnology and potentially relocated to Sanger Institute later in the project.

Successful candidates will be expected to drive forward the project, working closely with relevant members of the Institute and the wider scientific community to accomplish scientific objectives.

Essential Skills

  • A PhD in a relevant area of Biological Sciences, and a passion for problem solving 
  • Experience in a range of relevant molecular biology techniques 
  • The ability to effectively communicate with collaborators and occasionally present oral communication to large groups 
  • Proven independent working style, technical problem solving, data analysis and generation of novel ideas 
  • Experience in DNA manipulation technologies, especially approaches to deliver and site-specifically integrate large pieces of DNA into genomes and/or mitochondria 


Ideal Skills

  • Experience working with mitochondrial genomes 
  • Experience in genome editing and engineering 
  • Experience in yeast or E. coli synthetic biology 


Other information

The Wellcome Sanger Institute is a charitably funded research centre and committed to training the next generation of genome scientists. Focused on understanding the role of genetics in health and disease and a world leader in the genomic revolution, our mission is to use genome sequences to advance understanding of human and pathogen biology in order to improve human health. We aim to provide results that can be translated into diagnostics, treatments or therapies that reduce global health burdens. Our science is large-scale and organised into Programmes, led by our Faculty who conceive and deliver our science, and supported by our Scientific Operations teams responsible for all data production pipelines at the Institute.

Our Campus: Set over 125 acres, the stunning and dynamic Wellcome Genome Campus is the biggest aggregate concentration of people in the world working on the common theme of Genomes and BioData. It brings together a diverse and exceptional scientific community, committed to delivering life-changing science with the reach, scale and imagination to pursue some of humanity’s greatest challenges.

Our Benefits: Our employees have access to a comprehensive range of benefits and facilities including:

  • Group Defined Contribution Pension Scheme and Life Assurance
  • Group Income Protection
  • Private Health Insurance
  • 25 days annual leave, increasing by one day a year to a maximum of 30
  • Family friendly environment including options for flexible and part-time working, a childcare voucher scheme, Campus Nursery and Summer holiday club
  • Two days paid Employee Volunteering Leave a year
  • Employee Discount Scheme
  • Campus Gym, tennis courts and sports hall plus a range of dining facilities
  • Active Campus Sports and Social Club
  • Free Campus Bus Service

Genome Research Limited hold an Athena SWAN Bronze Award and will consider all individuals without discrimination and are committed to creating an inclusive environment for all employees, where everyone can thrive.

Please include a covering letter and CV with your application.  Closing date for applications: 3rd July 2019 


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The Synthetic Biology Strategic Research Initiative provides a hub for anyone interested in Synthetic Biology at the University of Cambridge, as well as commercial partners and external collaborators.